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天然化合物

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カタログ番号	製品名	別名	ターゲット
T2648	Pimecrolimus	SDZ-ASM 981,ASM 981	Others
	Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri...		Others
T0118	Mizolastine	SL 850324	Histamine Receptor
	Mizolastine (SL 850324) (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis), hives.		Histamine Receptor
T3148	MK-571 sodium	L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor , LTR
	MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ...		Leukotriene Receptor , LTR
T8239	Cromoglicic acid		Others
	Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.		Others
T28972	Tiaramide hydrochloride	FK-1160,NTA-194,FK 1160,FK1160,tiaramide	Others
	Tiaramide hydrochloride (FK-1160) is an anti-inflammatory drug that inhibits the action of mediators released from mast cells and has direct smooth muscle relaxant properties.		Others
T1260	Cromolyn sodium	Disodium Cromoglycate,FPL 670 (Cromolyn) Disodium,FPL-670,Sodium cromoglycate	Others , Potassium Channel , GSK-3 , Calcium Channel
	Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.		Others , Potassium Channel , GSK-3 , Calcium Channel
T1425	Pemirolast potassium	BMY 26517,TWT-8152	Histamine Receptor
	Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium (TWT-8152) exerts its action by blocking the antigen-mediated calcium ion influx i...		Histamine Receptor
T0173	Nylidrin hydrochloride	Buphenine HCl	Adrenergic Receptor
	Nylidrin hydrochloride (Buphenine HCl) was an effective inhibitor of the IgG1-mediated release of histamine from passively sensitized guinea pig lung slices, and of the IgE-mediated release of histamine from passively se...		Adrenergic Receptor
T1639	Amlexanox	CHX3673,Amoxanox,AA673	IL Receptor , FGFR , Others , IκB/IKK
	Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan...		IL Receptor , FGFR , Others , IκB/IKK
T3520	Setipiprant	KYTH-105,ACT-129968	GPR , Prostaglandin Receptor
	Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari...		GPR , Prostaglandin Receptor
T22879	JNJ 10191584 maleate	JNJ 10191584 maleate salt,VUF6002 maleate	Histamine Receptor
	JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM).		Histamine Receptor
T3979	Emedastine	LY188695,Emadine	Histamine Receptor
	Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its...		Histamine Receptor
T4657	WHI-P97		JAK
	WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane ...		JAK
T1139	Salbutamol	Albuterol,AH-3365	Adrenergic Receptor
	Salbutamol (Albuterol) stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Salbutamol ...		Adrenergic Receptor
TP1956L	PKC ζ pseudosubstrate acetate	PKC ζ pseudosubstrate acetate (799764-07-1 free base)	PKC
	PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by...		PKC
T26470	A1777	AA1777,AA-1777,AA 1777
	A1777, a selective 5-lipoxygenase inhibitor, reduces leukocytes proliferation without affecting the eosinophils of mast cells.
T19472	Nedocromil sodium	Nedocromil disodium salt,FPL 59002KP	Others
	Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.		Others
T34796	TEI-9063	TEI9063
	TEI-9063 is a stable and highly specific prostacyclin analogue of prostacyclin receptor in mast cell tumor p-815 cells.
T36713	Streptochlorin
	Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF...
T11473	GSK-5498A		Others
	GSK-5498A is a selective blocker of CARC (IC50, 1 μM). It inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety of species.		Others
T70193	APC-366 HCl
	APC-366 is a selective inhibitor of the mast cell tryptase that inhibits tryptase-induced histamine release from human tonsil and lung cells.
TP1408	Peptide 401
	Peptide 401 is an antimicrobial peptide (AMP) derived from the venom of bees and wasps. Peptide 401 induces mast cell degranulation, activating histamine release from peritoneal mast cells. Additionally, peptide 401 exhi...
T38127	PNPS-DHA
	pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide that has anti-allergic activity.1It inhibits degranulation of RBL-2H3 mast cells (IC50= 15 μM).pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cut...
T82176	HR1
	HR1, a mastoid protease, enhances the permeability of human erythrocyte membranes and can induce cytoplasmic membrane permeation in bacteria and mast cells [1].
TP1946	QWF
	Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced...
TQ0032L	Rosiptor acetate	AQX-1125,AQX 1125,AQX1125,AQX-1125 acetate
	Rosiptor is a potent and selective SHIP1 activator. AQX-1125 inhibits Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduces cytokine production in splenocytes, inhibits the activation of mast ...
T76095	Granuliberin R
	Granuliberin R, a dodecapeptide derived from the skin of the frog Rana rugosa, is a novel amphibian-origin mast cell degranulating peptide. It has the ability to target rat peritoneal mast cells, prompting them to releas...
T69059	Cromoglicate sodium hydrate
	Cromoglicic acid , cromolyn (USAN), cromoglycate (former BAN), or cromoglicate, is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. ...
T38227	Quin C1
	Potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts ...
T80764	Xenopsin-Related Peptide 2	XP-2
	Xenopsin-Related Peptide 2 (XP-2), an avian analog of amphibian Xenopsin, exhibits efficacy in histamine release from isolated rat mast cells comparable to that of synthetic Bradykinin [1].
T36545	Prostaglandin D2 methyl ester	Prostaglandin D2 methyl ester
	Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypoten...
T76919	Barzolvolimab
	Barzolvolimab (CDX 0159), a humanized anti-KIT IgG1 monoclonal antibody, specifically and potently inhibits KIT activation by SCF, thereby reducing skin mast cells and disease activity in chronic inducible urticaria [1].
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and ...
TP1956	PKC ζ pseudosubstrate
	Inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennap...
T38296	Alamethicin F50	Alamethicin F50
	Alamethicin F50 is a peptaibol isolated from Trichoderma. It is a polymer of 20 amino acids that includes modified and non-proteinogenic amino acids. Alamethicin F50 is a mixture of 13 different peptides, with the most a...
T38834	LYP-IN-1
	LYP-IN-1 is a powerful LYP inhibitor that demonstrates high potency, selectivity, and specificity, with a Ki of 110 nM and an IC 50 of 0.259 μM. Beyond its primary target, LYP-IN-1 also exhibits selectivity towards a wid...
T76869	Lirentelimab
	Lirentelimab (AK002), a humanized IgG1 monoclonal antibody, specifically targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). It promotes apoptosis in IL-5-activated eosinophils and suppresses IgE-mediated activation ...
T37604	ITK inhibitor
	Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine recept...
T70377	BAY 61-3606 HCl
	BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was sh...
T38126	PMX 53c
	Negative control for PMX 53. Active Analog also available. Subramanian et al (2011) PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. Mol.Pharmacol. 79 1005 PMID:21441599
TP1910	CALP1
	Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-...
TP2058	Catestatin
	Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signa...
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at...
T37492	11-trans Leukotriene C4	11-trans Leukotriene C4
	11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative...
T68701	Abarelix acetate
	Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In ...
T35731	Deethylindanomycin
	Deethylindanomycin is a polyether antibiotic that has been found in S. setonii. It is active against a variety of Gram-positive bacteria, including various strains of S. aureus and Streptococcus, as well as one strain of...
T78641	ER-27319		Syk
	ER-27319, an acridone derivative, serves as a potent and selective inhibitor of spleen tyrosine kinase (SYK), effectively impeding both the tyrosine phosphorylation and enzymatic activity of SYK. With an inhibitory conce...		Syk
T37261	14,15-Leukotriene D4	14,15-Leukotriene D4
	14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 ...
T37620	Leukotriene C4 methyl ester
	Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular met...
T37262	14,15-Leukotriene E4	14,15-Leukotriene E4
	Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metaboli...

Compounds

Pimecrolimus

T2648

Synonym: SDZ-ASM 981,ASM 981

Target: Histamine Receptor

MK-571 sodium

T3148

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

Tiaramide hydrochloride

T28972

Synonym: FK-1160,NTA-194,FK 1160,FK1160,tiaramide

Target: Others

Cromolyn sodium

T1260

Synonym: Disodium Cromoglycate,FPL 670 (Cromolyn) Disodium,FPL-670,Sodium cromoglycate

Target: Others, Potassium Channel, GSK-3, Calcium Channel

Pemirolast potassium

T1425

Synonym: BMY 26517,TWT-8152

Target: Histamine Receptor

Nylidrin hydrochloride

T0173

Synonym: Buphenine HCl

Target: Adrenergic Receptor

Amlexanox

T1639

Synonym: CHX3673,Amoxanox,AA673

Target: IL Receptor, FGFR, Others, IκB/IKK

Setipiprant

T3520

Synonym: KYTH-105,ACT-129968

Target: GPR, Prostaglandin Receptor

JNJ 10191584 maleate

T22879

Synonym: JNJ 10191584 maleate salt,VUF6002 maleate

Target: Histamine Receptor

Emedastine

T3979

Synonym: LY188695,Emadine

Target: Histamine Receptor

Synonym: Albuterol,AH-3365

Target: Adrenergic Receptor

PKC ζ pseudosubstrate acetate

TP1956L

Synonym: PKC ζ pseudosubstrate acetate (799764-07-1 free base)

Target: PKC

A1777

T26470

Synonym: AA1777,AA-1777,AA 1777

Target:

Nedocromil sodium

T19472

Synonym: Nedocromil disodium salt,FPL 59002KP

Synonym: AQX-1125,AQX 1125,AQX1125,AQX-1125 acetate

Cromoglicate sodium hydrate

Xenopsin-Related Peptide 2

T80764

Synonym: XP-2

Target:

Prostaglandin D2 methyl ester

T36545

Synonym: Prostaglandin D2 methyl ester

β-Defensin-3 (human) (trifluoroacetate salt)

T35452

Synonym:

Target:

PKC ζ pseudosubstrate

Synonym: Alamethicin F50

β-Defensin-4 (human) (trifluoroacetate salt)

T35453

Synonym:

Target:

11-trans Leukotriene C4

T37492

Synonym: 11-trans Leukotriene C4

Synonym: 14,15-Leukotriene D4

Target:

Leukotriene C4 methyl ester

Synonym: 14,15-Leukotriene E4

Target:

カタログ番号	製品名	別名	ターゲット
TN6737	(25R)-Spirost-4-ene-3,12-dione		Others
	(25R)-Spirost-4-ene-3,12-dione is a natural product.		Others
T6926	Palmitoylethanolamide	Mackpeart DR 14V,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol	Influenza Virus , Endogenous Metabolite , PPAR
	Palmitoylethanolamide (Impulsin) is an endogenously fatty acid amide. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective agent and an anticonvulsant.Upon administration, palmitoyleth...		Influenza Virus , Endogenous Metabolite , PPAR
TN1516	Cnidicin		NOS , NO Synthase
	Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the pr...		NOS , NO Synthase
T4S0797	Berberine	Berberin,Umbellatine	Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy
	1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3....
T5S2343	Acetylshikonin	Acetyl shikonin	Others , P450 , AChE
	1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang...		Others , P450 , AChE
T3S0027	Picropodophyllotoxin	AXL 1717,Picropodophyllin	IGF-1R
	Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti...		IGF-1R
TN3062	4'-O-Methylnyasol		Histamine Receptor
	4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells.		Histamine Receptor
TN6539	Pd-C-II
	Pd-C-II has anti-inflammation activity, it can inhibit TNF-α production and iNOS protein expression and inhibit COX-2 protein expression in LPS-stimulated RAW 264.7 cells. Pd-C-II inhibits anaphylactic mediator release f...
T25687	Leukotriene C4	LTC4,Leukotriene C
	Leukotriene C4 is the conjugation product of Leukotriene A4 and glutathione. It is the major arachidonic acid metabolite in human mast cells, macrophages, and antigen-sensitized lung tissue. It stimulates mucus secretion...
T80998	Thapsigargicin	Thapsigargicine
	Thapsigargicin (Thapsigargicine) acts as an activator for mast cells and leukocytes, prompting histamine release from rat peritoneal mast cells and human basophil leukocytes. Additionally, it elevates cytoplasmic free ca...
TN5647	Confluentin
	Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxici...
TN4392	Koaburaside		IL Receptor , TNF , Influenza Virus
	Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histam...		IL Receptor , TNF , Influenza Virus
TN6667	Spinacetin
	Spinacetin has anti-inflammatory effects, it weakly inhibited nitric oxide production and reduced prostaglandin E2 levels to different extents. It shows the activities in preventing inflammatory processes, which might be...
TN3325	9-O-Feruloyl-5,5'-dimethoxylariciresinol		IL Receptor , TNF
	(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cytotoxicity against a small panel of human tumor cell lines, ...		IL Receptor , TNF
TN1009	Epimagnolin B		NF-κB , NO Synthase , Prostaglandin Receptor
	Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear transl...		NF-κB , NO Synthase , Prostaglandin Receptor
TN4683	Nyasol		ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt , Antifection
	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antif...
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble ...
T38285	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))	Others
	C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) is the predominant sulfate analog in the mature myelin sheath. C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z)) interacted with C-type lectin and immunoglobulin-like...		Others

天然物製品

(25R)-Spirost-4-ene-3,12-dione

TN6737

Synonym:

Target: Others

Palmitoylethanolamide

T6926

Synonym: Mackpeart DR 14V,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol

Target: Influenza Virus, Endogenous Metabolite, PPAR

Cnidicin

TN1516

Synonym:

Target: NOS, NO Synthase

Berberine

T4S0797

Synonym: Berberin,Umbellatine

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Acetylshikonin

T5S2343

Synonym: Acetyl shikonin

Target: Others, P450, AChE

Picropodophyllotoxin

T3S0027

Synonym: AXL 1717,Picropodophyllin

Target: Histamine Receptor

Synonym: LTC4,Leukotriene C

Target:

Thapsigargicin

T80998

Synonym: Thapsigargicine

Target: IL Receptor, TNF, Influenza Virus

9-O-Feruloyl-5,5'-dimethoxylariciresinol

TN3325

Synonym:

Target: IL Receptor, TNF

Epimagnolin B

TN1009

Synonym:

Target: NF-κB, NO Synthase, Prostaglandin Receptor

Nyasol

TN4683

Synonym:

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt, Antifection

9(S),12(S),13(S)-TriHOME

T37272

Synonym:

Target:

C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))

T38285

Synonym: C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00051	IL-3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPJ-01204	TPSAB1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(T...
TMPJ-01465	GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)	Human	E. coli
	Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of...
TMPJ-00042	TSLP Protein, Human, Recombinant	Human	E. coli
	Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino aci...
TMPK-00212	CD300A Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.C...
TMPK-00559	CD300A Protein, Cynomolgus, Recombinant (Avi)	Cynomolgus	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.C...
TMPH-02499	Allergin-1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction. Allergin-1...
TMPH-02581	Chymase 1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Chymase 1 Protein, Mouse, Recombinant (His) is expressed i...
TMPK-00186	CD300A Protein, Human, Recombinant (Avi)	Human	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.C...
TMPK-00560	CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated	Cynomolgus	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.C...
TMPJ-00187	CD300A Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	CD300A is a single-pass type I membrane protein which belongs to the CD300 family. It contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD300 family of myeloid immunoglobulin receptors includes activating (CD30...
TMPK-00187	CD300A Protein, Human, Recombinant (Avi), Biotinylated	Human	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.C...
TMPK-00561	CD300A Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.C...
TMPK-00033	IL-3 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPK-00031	IL-3 Protein, Human, Recombinant (His & Avi)	Human	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPK-00032	IL-3 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPK-00655	IL-3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPJ-00542	TPSB2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Tryptases are Trypsin-like Serine Proteases. β-Tryptases are the main isoenzymes in mast cells. Βtryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites faci...
TMPH-02257	TPSB2 Protein, Human, Recombinant (His & Myc)	Human	P. pastoris (Yeast)
	Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSB2 Protein, Human, Recombinant (Hi...
TMPH-02258	TPSB2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSB2 Protein, Human, Recombinant (E....
TMPY-03968	Secretogranin II Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KI...
TMPH-03396	TPSAB1 Protein, Rat, Recombinant (His & Myc & SUMO)	Rat	E. coli
	Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSAB1 Protein, Rat, Recombinant (His...
TMPH-03328	Mcpt1 Protein, Rat, Recombinant (Myc)	Rat	E. coli
	Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. May participate in generating perivascular beta-protein wh...
TMPJ-00402	CD117 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to ...
TMPK-00482	TSLP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated	Cynomolgus	HEK293 Cells
	Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ...
TMPK-00038	TSLP Protein, Human, Recombinant (R127A & R130A, His & Avi)	Human	HEK293 Cells
	Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ...
TMPK-00049	IL-3 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPK-00590	IL-3 Protein, Human, Recombinant (E. coli)	Human	E. coli
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPJ-00281	CADM1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. C...
TMPK-00026	IL-9 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pl...
TMPK-00568	IL-9 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pl...
TMPH-03267	CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)	Rat	E. coli
	Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which...
TMPH-02957	TPSAB1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSAB1 Protein, Mouse, Recombinant (H...
TMPH-03390	TRPV2 Protein, Rat, Recombinant (His)	Rat	E. coli
	Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce phys...
TMPJ-00898	CD72 Protein, Human, Recombinant (Trx & His)	Human	E. coli
	B-Cell Differentiation Antigen CD72 (CD72) is a single-pass type II membrane protein. CD72 exists as a disulfide-linked homodimer and contains one C-type lectin domain. CD72 is expressed on B lineage cells, NK cells, mon...
TMPK-01303	TPSAB1 protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	TPSAB1, namely tryptase alpha/beta-1, is a serine protease with trypsinlike activity. TPSAB1 is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this...
TMPK-00040	TSLP Protein, Human, Recombinant (R127A & R130A, His & Avi), Biotinylated	Human	HEK293 Cells
	Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ...
TMPK-00039	TSLP Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ...
TMPK-00037	TSLP Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of ...
TMPJ-00233	CD200R1/CRTR2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain ...
TMPK-00617	IL-13 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast ce...
TMPK-00025	IL-9 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pl...
TMPJ-01338	TSLP Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family, contains 140 amino acids. It is known to play an important role in the maturation of T cell populations through activation of antigen pre...
TMPJ-01323	NTAL Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Linker for Activation of T-Cells Family Member 2 (LAT2) is a single-pass type III membrane protein. LAT2 is highly expressed in the spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. LAT2 is invol...
TMPK-00149	Fc epsilon RI alpha/FCER1a Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a high-affinity IgE re...
TMPY-02242	Serpin B6 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-...
TMPY-01027	Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. I...
TMPK-01165	MCEMP1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	A cecal ligation and puncture-induced sepsis mouse model was established to determine the expression of mast cell expression membrane protein 1 (MCEMP1). MCEMP1 in T lymphocytes isolated from sepsis mice were up- or down...
TMPH-03296	Galectin-3/LGALS3 Protein, Rat, Recombinant (His)	Rat	E. coli
	Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute infl...
TMPJ-00895	SCF Protein, Rat, Recombinant (HEK293, His)	Rat	HEK293 Cells
	SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, ...
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IL-3 Protein, Mouse, Recombinant (His)

TMPJ-00051

Species: Mouse

Expression System: HEK293 Cells

TPSAB1 Protein, Human, Recombinant (His)

TMPJ-01204

Species: Human

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)

TMPJ-01465

Species: Human

Expression System: E. coli

TSLP Protein, Human, Recombinant

TMPJ-00042

Species: Human

Expression System: E. coli

CD300A Protein, Mouse, Recombinant (His)

TMPK-00212

Species: Mouse

Expression System: HEK293 Cells

CD300A Protein, Cynomolgus, Recombinant (Avi)

TMPK-00559

Species: Cynomolgus

Expression System: HEK293 Cells

Allergin-1 Protein, Mouse, Recombinant (His & Myc)

TMPH-02499

Species: Mouse

Expression System: E. coli

Chymase 1 Protein, Mouse, Recombinant (His)

TMPH-02581

Species: Mouse

Expression System: E. coli

CD300A Protein, Human, Recombinant (Avi)

TMPK-00186

Species: Human

Expression System: HEK293 Cells

CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated

TMPK-00560

Species: Cynomolgus

Expression System: HEK293 Cells

CD300A Protein, Human, Recombinant (hFc & His)

TMPJ-00187

Species: Human

Expression System: HEK293 Cells

CD300A Protein, Human, Recombinant (Avi), Biotinylated

TMPK-00187

Species: Human

Expression System: HEK293 Cells

CD300A Protein, Cynomolgus, Recombinant (His)

TMPK-00561

Species: Cynomolgus

Expression System: HEK293 Cells

IL-3 Protein, Human, Recombinant (hFc)

TMPK-00033

Species: Human

Expression System: HEK293 Cells

IL-3 Protein, Human, Recombinant (His & Avi)

TMPK-00031

Species: Human

Expression System: E. coli

IL-3 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00032

Species: Human

Expression System: E. coli

IL-3 Protein, Cynomolgus, Recombinant (His)

TMPK-00655

Species: Cynomolgus

Expression System: E. coli

TPSB2 Protein, Human, Recombinant (His)

TMPJ-00542

Species: Human

Expression System: HEK293 Cells

TPSB2 Protein, Human, Recombinant (His & Myc)

TMPH-02257

Species: Human

Expression System: P. pastoris (Yeast)

TPSB2 Protein, Human, Recombinant (E. coli, His)

TMPH-02258

Species: Human

Expression System: E. coli

Secretogranin II Protein, Human, Recombinant (His)

TMPY-03968

Species: Human

Expression System: HEK293 Cells

TPSAB1 Protein, Rat, Recombinant (His & Myc & SUMO)

TMPH-03396

Species: Rat

Expression System: E. coli

Mcpt1 Protein, Rat, Recombinant (Myc)

TMPH-03328

Species: Rat

Expression System: E. coli

CD117 Protein, Human, Recombinant (hFc)

TMPJ-00402

Species: Human

Expression System: HEK293 Cells

TSLP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

TMPK-00482

Species: Cynomolgus

Expression System: HEK293 Cells

TSLP Protein, Human, Recombinant (R127A & R130A, His & Avi)

TMPK-00038

Species: Human

Expression System: HEK293 Cells

IL-3 Protein, Mouse, Recombinant (hFc)

TMPK-00049

Species: Mouse

Expression System: HEK293 Cells

IL-3 Protein, Human, Recombinant (E. coli)

TMPK-00590

Species: Human

Expression System: E. coli

CADM1 Protein, Mouse, Recombinant (hFc)

TMPJ-00281

Species: Mouse

Expression System: HEK293 Cells

IL-9 Protein, Mouse, Recombinant (hFc)

TMPK-00026

Species: Mouse

Expression System: HEK293 Cells

IL-9 Protein, Cynomolgus, Recombinant (His)

TMPK-00568

Species: Cynomolgus

Expression System: HEK293 Cells

CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)

TMPH-03267

Species: Rat

Expression System: E. coli

TPSAB1 Protein, Mouse, Recombinant (His)

TMPH-02957

Species: Mouse

Expression System: E. coli

TRPV2 Protein, Rat, Recombinant (His)

TMPH-03390

Species: Rat

Expression System: E. coli

CD72 Protein, Human, Recombinant (Trx & His)

TMPJ-00898

Species: Human

Expression System: E. coli

TPSAB1 protein, Cynomolgus, Recombinant (His)

TMPK-01303

Species: Cynomolgus

Expression System: E. coli

TSLP Protein, Human, Recombinant (R127A & R130A, His & Avi), Biotinylated

TMPK-00040

Species: Human

Expression System: HEK293 Cells

TSLP Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00039

Species: Human

Expression System: HEK293 Cells

TSLP Protein, Human, Recombinant (His & Avi)

TMPK-00037

Species: Human

Expression System: HEK293 Cells

CD200R1/CRTR2 Protein, Human, Recombinant (His)

TMPJ-00233

Species: Human

Expression System: HEK293 Cells

IL-13 Protein, Human, Recombinant (His & Avi)

TMPK-00617

Species: Human

Expression System: HEK293 Cells

IL-9 Protein, Human, Recombinant (hFc)

TMPK-00025

Species: Human

Expression System: HEK293 Cells

TSLP Protein, Mouse, Recombinant (hFc)

TMPJ-01338

Species: Mouse

Expression System: HEK293 Cells

NTAL Protein, Human, Recombinant (His)

TMPJ-01323

Species: Human

Expression System: HEK293 Cells

Fc epsilon RI alpha/FCER1a Protein, Human, Recombinant (His)

TMPK-00149

Species: Human

Expression System: HEK293 Cells

Serpin B6 Protein, Human, Recombinant (His)

TMPY-02242

Species: Human

Expression System: Baculovirus Insect Cells

Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)

TMPY-01027

Species: Mouse

Expression System: HEK293 Cells

MCEMP1 Protein, Mouse, Recombinant (hFc)

TMPK-01165

Species: Mouse

Expression System: HEK293 Cells

Galectin-3/LGALS3 Protein, Rat, Recombinant (His)

TMPH-03296

Species: Rat

Expression System: E. coli

SCF Protein, Rat, Recombinant (HEK293, His)

TMPJ-00895

Species: Rat

Expression System: HEK293 Cells

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カタログ番号	製品名
L3300	Histamine & Melatonin Receptor-Targeted Compound Library		153 compounds
	A unique collection of 153 compounds targeting histaminergic receptor and melatonin receptor for high throughput screening (HTS) and high content screening (HCS) for new drugs;

ライブラリー

Histamine & Melatonin Receptor-Targeted Compound Library

L3300

Compounds: 153